Geng Lab - Publications

Geng lab publications

2026

Baixi He, Yuxuan Mao, Catherine Hong, Yijie Geng. Top2a-dependent neuronal regulation of social behavior and persistent rescue of social deficit through PRC2-mediated epigenetic reprogramming. bioRxiv. 2026 Feb 26. doi: 10.64898/2026.02.24.707855.

Kunrong Wang, Ping Zhang, Yijie Geng. High-Precision Pneumatic Induction of Traumatic Brain Injury in Larval Zebrafish. bioRxiv. 2026 Feb 26. doi: 10.64898/2026.02.24.707859.

Maja Johnson, Aiden F Eno, Karl Stuntzner-Gibson, James W MacDonald, Theo K Bammler, Yijie Geng. EpiBrain: the brain's epigenetic landscape in a snapshot. bioRxiv. 2026 Jan 23. doi: 10.64898/2026.01.22.701139. PMCID: PMC12871645. PMID: 41648188.

2025

Leonardo Diaz*, Ally Xinyi Kong*, Ping Zhang*, Jinhua Chi, Khoa Pham, Maja Johnson, Aiden Eno, Isabelle Douglas, Yuxuan Mao, James W MacDonald, Julia Yue Cui, Theo Bammler, Haiwei Gu, Yijie Geng. Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases. bioRxiv. 2025 Oct 20. doi: 10.1101/2025.10.19.683261. PMCID: PMC12633377. PMID: 41280077.

*These authors contributed equally

2024

Debad SJ, Aungst J, Carstens K, Ferrer M, Fitzpatrick S, Fritsche E, Geng Y, Hartung T, Hogberg HT, Li R, Mangas I, Marty S, Musser S, Perron M, Rattan S, Rüegg J, Sachana M, Schenke M, Shafer TJ, Smirnova L, Talpos J, Tanguay RL, Terron A, Bandele O. State of the science on assessing developmental neurotoxicity using new approach methods . ALTEX. 2024 Dec 9. DOI: 10.14573/altex.2410231. PMID: 39675048.

Ally Xinyi Kong*, Maja Johnson*, Aiden F Eno, Khoa Pham, Ping Zhang, Yijie Geng. Proteome-wide reverse molecular docking reveals folic acid receptor as a mediator of PFAS-induced neurodevelopmental toxicity. bioRxiv. 2024 Nov 11. doi: 10.1101/2024.11.11.623082. PMCID: PMC11601370. PMID: 39605555.

*These authors contributed equally

Selected publications before starting the lab at UW in 2023

Geng Y, Yates C, Peterson RT. Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality. Cell Rep Methods. 2023 Jan 23;3(1):100381. doi: 10.1016/j.crmeth.2022.100381. eCollection 2023 Jan 23. PubMed PMID: 36814839; PubMed Central PMCID: PMC9939379.

Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT. Top2a promotes the development of social behavior via PRC2 and H3K27me3. Sci Adv. 2022 Nov 25;8(47):eabm7069. doi: 10.1126/sciadv.abm7069. Epub 2022 Nov 23. PubMed PMID: 36417527; PubMed Central PMCID: PMC9683714.

Geng Y, Peterson RT. Rapid Mounting of Zebrafish Larvae for Brain Imaging. Zebrafish. 2021 Dec;18(6):376-379. doi: 10.1089/zeb.2021.0062. PubMed PMID: 34935498; PubMed Central PMCID: PMC8716516.

Geng Y, Peterson RT. The zebrafish subcortical social brain as a model for studying social behavior disorders. Dis Model Mech. 2019 Aug 6;12(8). doi: 10.1242/dmm.039446. Review. PubMed PMID: 31413047; PubMed Central PMCID: PMC6737945.

Geng Y, Feng B. A small molecule-based strategy for endothelial differentiation and three-dimensional morphogenesis from human embryonic stem cells. Heliyon. 2016 Jul;2(7):e00133. doi: 10.1016/j.heliyon.2016.e00133. eCollection 2016 Jul. PubMed PMID: 27512727; PubMed Central PMCID: PMC4971129.

Geng Y, Zhao Y, Schuster LC, Feng B, Lynn DA, Austin KM, Stoklosa JD, Morrison JD. A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency. Stem Cell Reports. 2015 Dec 8;5(6):1143-1154. doi: 10.1016/j.stemcr.2015.09.023. Epub 2015 Nov 5. PubMed PMID: 26549849; PubMed Central PMCID: PMC4682066.

Geng Y, Feng B. Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis. Heliyon. 2015 Dec 1;1(4):e00046. doi: 10.1016/j.heliyon.2015.e00046. PubMed PMID: 26705539; PubMed Central PMCID: PMC4685751.